Normal cortical excitability in Myoclonus-Dystonia--a TMS study
| Autor: | Elisabeth M. J. Foncke, Kailash P. Bhatia, John C. Rothwell, Lo J. Bour, A.F. van Rootselaar, Johannes H. T. M. Koelman, Marina A. J. Tijssen, S. M. A. van der Salm |
|---|---|
| Přispěvatelé: | ANS - Amsterdam Neuroscience, Graduate School, Neurology |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Myoclonus Movement disorders medicine.medical_treatment PATHOPHYSIOLOGY Polyphasic MEP Neurological disorder Functional Laterality Statistics Nonparametric Young Adult Developmental Neuroscience medicine Reaction Time Humans Peripheral Nerves Evoked potential EPSILON-SARCOGLYCAN RATING-SCALE PLASTICITY Dystonia HUMAN MOTOR CORTEX Cerebral Cortex Electromyography HAND DYSTONIA WRITERS CRAMP Neural Inhibition INTRACORTICAL INHIBITION Middle Aged medicine.disease Myoclonus-Dystonia Evoked Potentials Motor FACILITATION Transcranial Magnetic Stimulation Electric Stimulation Transcranial magnetic stimulation Neurology Dystonic Disorders Case-Control Studies Silent period Female medicine.symptom Psychology Neuroscience Dystonic disorder |
| Zdroj: | Experimental Neurology, 216(2), 300-305. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS Experimental neurology, 216(2), 300-305. Academic Press Inc. |
| ISSN: | 1090-2430 0014-4886 |
| Popis: | Objective: The aim of the present study is to investigate cortical excitability in patients with DYT 11 positive Myoclonus-Dystonia (M-D), using transcranial magnetic stimulation (TMS).Methods: Silent period, motor evoked potential (MEP) recruitment curve short interval intracortical, inhibition (SICI), intracortical facilitation (ICF) and short interval intracortical facilitation (SICF), with short interstimulus intervals (ISIs) ranging from 1.2 to 3.2 ms, were studied in 15 DYT 11-positive M-D patients and their matched controls. In four patients and matched controls peripheral double pulse electrical nerve stimulation was performed.Results: All TMS parameters of cortical excitability were normal compared to healthy controls. In the SICF protocol we observed more variable and polyphasic MEPs in M-D patients. Cross-covariance analysis of MEP area revealed a significant correlation difference at ISI 2.2 and 2.8 ms. This increased variability was not seen in other TMS protocols or with peripheral nerve stimulation.Conclusions: In contrast with other types of dystonia, no changes in cortical excitability were found in DYT 11 patients. Our findings suggest that M-D is both clinically and pathophysiologically a separate entity from other dystonic disorders. Polyphasic MEPs during the SICF protocol in M-D patients could reflect central neuron membrane instability. Application of the SICF protocol in other patient groups has to prove its value in movement disorders. (c) 2008 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect