Influence of endocrine therapy on the ratio of androgen receptor (AR) to estrogen receptor (ER) positive circulating epithelial tumor cells (CETCs) in breast cancer
| Autor: | Dorothea Schott, Monika Pizon, Katharina Pachmann, Ulrich Pachmann, Daniel Lux |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Antineoplastic Agents Hormonal medicine.drug_class Estrogen receptor lcsh:Medicine Breast Neoplasms General Biochemistry Genetics and Molecular Biology Young Adult 03 medical and health sciences 0302 clinical medicine Breast cancer Cell Line Tumor medicine Humans Androgen to estrogen ratio Aromatase inhibitor business.industry Research lcsh:R Epithelial Cells General Medicine Middle Aged Neoplastic Cells Circulating medicine.disease Androgen receptor Tamoxifen 030104 developmental biology Receptors Estrogen Receptors Androgen 030220 oncology & carcinogenesis Cancer research Biomarker (medicine) Female Lymph Nodes Lymph business medicine.drug Hormone Circulating epithelial tumor cells |
| Zdroj: | Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-9 (2018) Journal of Translational Medicine |
| ISSN: | 1479-5876 |
| Popis: | Background The androgen receptor (AR) is expressed in the majority of breast cancers and across the main breast cancer subtypes. Despite the high frequency of AR expression in breast cancer its appraisal remains controversial because its role is complex, dependent on the hormonal milieu. The aim of the current study was to investigate the frequency of AR and ER positive CETCs in breast cancer patients. Methods The number of vital CETCs was determined from blood of 66 patients suffering from breast cancer and the expression of AR and ER on these cells was investigated using the maintrac method. Results Numbers of CETCs/mL blood were significantly higher in patients with advanced disease as compared to patients with early stage disease. The fraction of AR positive CETCs was significantly higher than the fraction of ER positive CETCs (90% vs. 50%; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |