A Biochemical Perspective of the Nonstructural Proteins (NSPs) and the Spike Protein of SARS CoV-2
| Autor: | Francis K. Yoshimoto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
2019-20 coronavirus outbreak
Proteases viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) SARS CoV-2 Bioengineering Viral Nonstructural Proteins Biology Biochemistry Article Virus Analytical Chemistry 03 medical and health sciences Pandemic Humans skin and connective tissue diseases 030304 developmental biology Infectivity 0303 health sciences SARS-CoV-2 030302 biochemistry & molecular biology Organic Chemistry COVID-19 Spike Protein Viral proteins Virology Enzymes Spike Glycoprotein Coronavirus Shut down |
| Zdroj: | The Protein Journal |
| ISSN: | 1875-8355 1572-3887 |
| Popis: | The global pandemic that shut down the world in 2020 was caused by the virus, SARS CoV-2. The chemistry of the various nonstructural proteins (NSP3, NSP5, NSP12, NSP13, NSP14, NSP15, NSP16) of SARS CoV-2 is discussed. Secondly, a recent major focus of this pandemic is the variant strains of SARS CoV-2 that are increasingly occurring and more transmissible. One strain, called “D614G”, possesses a glycine (G) instead of an aspartate (D) at position 614 of the spike protein. Additionally, other emerging strains called “501Y.V1” and “501Y.V2” have several differences in the receptor binding domain of the spike protein (N501Y) as well as other locations. These structural changes may enhance the interaction between the spike protein and the ACE2 receptor of the host, increasing infectivity. The global pandemic caused by SARS CoV-2 is a rapidly evolving situation, emphasizing the importance of continuing the efforts to interrogate and understand this virus. Supplementary Information The online version contains supplementary material available at 10.1007/s10930-021-09967-8. |
| Databáze: | OpenAIRE |
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