Nonsteroidal anti-inflammatory drugs--the clinical dilemmas
| Autor: | McCarthy Dm |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Gastrointestinal Diseases Perforation (oil well) Asymptomatic Epigastric tenderness Anti-inflammatory chemistry.chemical_compound Risk Factors Internal medicine Medicine Humans Stomach Ulcer Aspirin Nonsteroidal biology business.industry Anti-Inflammatory Agents Non-Steroidal Gastroenterology Helicobacter pylori biology.organism_classification digestive system diseases Surgery Hospitalization chemistry Duodenal Ulcer Peptic Ulcer Perforation Ulcer disease medicine.symptom business Gastrointestinal Hemorrhage medicine.drug |
| Zdroj: | Scandinavian journal of gastroenterology. Supplement. 192 |
| ISSN: | 0085-5928 |
| Popis: | Physicians using nonsteroidal anti-inflammatory drugs (NSAIDs) are concerned that effective anti-inflammatory doses cause few gastrointestinal side effects. Among the causes of discontinuing therapy, upper gastrointestinal symptoms and the development of ‘ulcer’ complications are major concerns; endoscopic findings in asymptomatic users are not. Initial symptoms, poorly correlated with endoscopic findings, are relieved by anti-ulcer drugs and ameliorate with time of NSAID use in most patients. Symptoms accompanied by epigastric tenderness, or unrelieved by H2 antagonists, or resulting in cessation of NSAID therapy are more predictive of underlying ulcers. Complications probably arise in several ways, including as hemorrhages due to interference with platelet function, and as complications due to exacerbations of underlying ulcer disease or of ulcers caused by the NSAIDs. Pathogenesis and effective prophylaxis (yet to be established) may therefore vary in different patients, a clinical dilemma. |
| Databáze: | OpenAIRE |
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