Estrogen receptor genes polymorphisms determine serum lipid profile in healthy postmenopausal women treated with calcium, vitamin D, and genistein
| Autor: | Ricardo Usategui-Martín, María Pérez-Alonso, Ismael Calero-Paniagua, D.A. de Luis, Antonio Dueñas-Laita, Laisa Socorro-Briongos, Lidia Linares, José Luis Pérez-Castrillón, Marta Ruiz-Mambrilla |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Genotype medicine.drug_class Estrogen receptor Genistein chemistry.chemical_element Calcium Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Internal medicine Vitamin D and neurology Medicine Humans Prospective Studies Vitamin D Molecular Biology Polymorphism Genetic medicine.diagnostic_test Triglyceride business.industry Cell Biology Middle Aged medicine.disease Menopause Postmenopause 030104 developmental biology Endocrinology chemistry Receptors Estrogen Estrogen 030220 oncology & carcinogenesis Female business Lipid profile |
| Zdroj: | Journal of cellular biochemistry. 120(8) |
| ISSN: | 1097-4644 |
| Popis: | Cardiovascular risk increases in women after menopause. Unfavorable lipid-lipoprotein changes due to a lack of estrogens may have an important role in this context. Estrogen actions are mainly mediated by their binding to two estrogen receptors (ERs) whose signaling may be conditioned by different factors. Calcium, vitamin D, and genistein, among others, cause a beneficial effect on serum lipid profile by its modulation. Some genetic factors can also determine this signal. We determined the possible additive effect of genistein on calcium and vitamin D supplementation regarding serum lipid profile changes and whether ER polymorphisms may mediate in this effect. We performed a prospective, double blind study in which women were randomized in two groups: one group received calcium and vitamin D and the other group received calcium, vitamin D and genistein. Subsequently, we studied rs9340799, rs928554, and rs4986938 ER polymorphisms in both groups. Our results showed that being a carrier of the variant allele G of rs928554 polymorphism was associated with a greater decrease in triglyceride levels and that the homozygous AA genotype of rs9340799 polymorphism was associated with a greater decrease in total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels after calcium, vitamin D, and genistein supplementation. This is the first report showing an association between polymorphisms in ER genes and an improvement of the serum lipid profile after taking calcium, vitamin D, and genistein supplementation in postmenopausal women. It reinforces the hypothesis that genetic factors are crucial in ER signalling. |
| Databáze: | OpenAIRE |
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