Can the cycle threshold (Ct) value of RT-PCR test for SARS CoV2 predict infectivity among close contacts?
| Autor: | Hayat S. Khogali, Aiman Elberdiny, Dina Ali, Mohammed Al-Thani, Hamad Al-Romaihi, Soha Al Bayat, Jesha Mundodan, Saif Alateeg, Samina Hasnain, Mohamed Sallam, Mohamed Osama |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
HP-CDC Health Protection and Communicable Disease Control Coronavirus disease 2019 (COVID-19) Isolation (health care) RT-PCR Value (computer science) MOPH Ministry of Public Health Infectious and parasitic diseases RC109-216 Isolation Ct value Contact tracing Internal medicine Humans Medicine COVID-19 coronavirus disease 2019 Infectivity Cycle threshold Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 business.industry Public Health Environmental and Occupational Health COVID-19 General Medicine Test (assessment) Infectious Diseases Real-time polymerase chain reaction Quarantine Close contacts Original Article Public aspects of medicine RA1-1270 Cycle threshold value business |
| Zdroj: | Journal of Infection and Public Health, Vol 14, Iss 9, Pp 1201-1205 (2021) Journal of Infection and Public Health |
| ISSN: | 1876-0341 |
| Popis: | Background: COVID-19 global pandemic is an unprecedented health emergency. Rapid identification and isolation of infected individuals is crucial. Qatar’s National Health Strategic Command Group adopted a cut off 30 for Ct value of RT-PCR result of a positive case to decide on duration of isolation and quarantine period for their close contacts. Aim: To test if Ct value cut off 30 reflects on the infectivity potential among close contacts. Methodology: All positive cases reported during July’ 2020 whose contacts had been traced and swabbed were extracted from database after removing personal identifiers. Close-contact was defined as anybody who has been within 2 m distance of a confirmed positive case for 15 min or more, without any personal protection equipment. Descriptive analysis was done and test of significance of difference in positivity among the contacts of those with ct < 30 and >30 was done. Results: 2308 COVID-19 positive cases were followed up. More than three-quarters had a Ct value < 30, with a mean Ct value of 24.05(+6.48). On an average 6 contacts were swabbed per case. More than half the positive cases followed up had at least one secondary case, with median positivity rate 12.5%. A significant relation was noted between Ct value cut-off 30 and secondary transmission (1.5 times more risk among those with Ct value < 30). A significant difference was noted in median positivity rate between close contacts of positive cases with Ct value > 30 or |
| Databáze: | OpenAIRE |
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