Gut adaptation and the insulin-like growth factor system: regulation by glutamine and IGF-I administration
| Autor: | Thomas R. Ziegler, J. L. Rombeau, Robert J. Smith, M. P. Mantell, Jesse C. Chow |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Transcription Genetic Physiology Glutamine medicine.medical_treatment Ileum Biology Enteral administration Rats Sprague-Dawley Insulin-like growth factor Enteral Nutrition Physiology (medical) Internal medicine Intestine Small medicine Animals Humans RNA Messenger Insulin-Like Growth Factor I Hyperplasia Hepatology Gastroenterology Muscle Smooth medicine.disease Short bowel syndrome Recombinant Proteins Small intestine Rats Insulin-Like Growth Factor Binding Protein 3 medicine.anatomical_structure Endocrinology Parenteral nutrition Insulin-Like Growth Factor Binding Protein 4 Liver Food Fortified |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 271:G866-G875 |
| ISSN: | 1522-1547 0193-1857 |
| DOI: | 10.1152/ajpgi.1996.271.5.g866 |
| Popis: | Intestinal adaptation after extensive small bowel resection in rats is augmented by the provision of diets supplemented with the amino acid glutamine (Gln) or by administration of insulin-like growth factor-I (IGF-I). The goal of this study was to investigate potential synergistic effects of Gln and IGF-I on postresection ileal hyperplasia. Rats underwent 80% small bowel resection (SBR) and then were fed low-Gln or L-Gln-enriched diets and subcutaneously given recombinant human IGF-I or vehicle for 7 days. Gln and IGF-I each significantly enhanced adaptive ileal hyperplasia (DNA content) compared with rats receiving vehicle and low-Gln diet. Ileal DNA content was highest when IGF-I was administered together with Gln supplementation. Combined IGF-I plus Gln synergistically increased ileal weight and protein content. This was associated with higher plasma concentrations of IGF-I and Gln than observed when IGF-I or Gln was given individually. Ileal IGF-I mRNA expression rose nearly twofold during gut adaptation after SBR; this response was augmented with IGF-I administration but was unaltered by Gln feeding. In contrast, dietary Gln, but not IGF-I therapy, prevented a decrease in hepatic IGF-I mRNA induced by SBR. We conclude that parenteral IGF-I and enteral Gln have both individual and synergistic effects on ileal adaptation after massive small intestinal resection. These findings support the concept that specific gut-trophic nutrients and growth factors may be combined to enhance intestinal adaptation and possibly reduce the severity of short bowel syndrome after intestinal resection. |
| Databáze: | OpenAIRE |
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