HLA A1, B8, DR3 extended haplotypes in autoimmune chronic hepatitis
| Autor: | Paul Emery, Marjorie Coggan, Philip G. Board, Ian R. Mackay, Brian Tait, Glenn Eckardt |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
musculoskeletal diseases
Male Human leukocyte antigen Biology Major histocompatibility complex Autoimmune Diseases HLA-B8 Antigen HLA-DR3 Antigen medicine Humans Allele Alleles HLA-A1 Antigen Hepatitis Chronic Hepatitis Genetics Autoimmune disease Hepatology HLA-A Antigens Histocompatibility Testing Haplotype Gastroenterology C4A Complement System Proteins HLA-DR Antigens medicine.disease Null allele Haplotypes HLA-B Antigens Immunology biology.protein Female |
| Zdroj: | Gastroenterology. 97(2) |
| ISSN: | 0016-5085 |
| Popis: | Genetic determinants of the autoimmune type of chronic active hepatitis include the major histocompatibility complex alleles HLA-B8 and HLA-DR3, which are usually present as the haplotype A1, B8, DR3. In certain other autoimmune diseases, an extended haplotype including complement alleles confers a greater relative risk than does B8, DR3. Hence, extended haplotypes were ascertained in autoimmune chronic active hepatitis by typing for HLA, complement alleles C4A, C4B, and Bf, and glyoxalase type 1 or 2. Eight of the 10 B8, DR3 haplotypes were A1, B8, DR3. Of the 8, 7 had the extended haplotype A1, B8, C4AQ0, C4B1, BfS, DR3, but this haplotype occurred in four instances with glyoxalase 2 and in three with glyoxalase 1. Thus, we find that in autoimmune chronic active hepatitis there is a high frequency of null alleles for complement but an extended haplotype does not cause any greater risk for disease than B8, DR3 alone. |
| Databáze: | OpenAIRE |
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