A Double-Blind Controlled Study to Evaluate the Effects of Yogurt Enriched with Lactococcus lactis 11/19-B1 and Bifidobacterium lactis on Serum Low-Density Lipoprotein Level and Antigen-Specific Interferon-γ Releasing Ability
| Autor: | Ken Ishioka, Ryoko Kanno, Nozomu Miyazaki, Tatsuo Suzutani, Yoshihisa Watanabe, Tetsuo Koshizuka, Yuko Sato, Kyoko Nishiyama, Riki Kikuchi, Takahiro Kobayashi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Blood Glucose Male Cellular immunity Blood lipids Blood sugar lcsh:TX341-641 medicine.disease_cause Article double-blind controlled study 03 medical and health sciences chemistry.chemical_compound Interferon-gamma Young Adult Lactobacillus acidophilus Bifidobacterium animalis Double-Blind Method medicine Humans Food science Lactococcus lactis Aged Glycated Hemoglobin 030109 nutrition & dietetics Nutrition and Dietetics biology Streptococcus food and beverages Cholesterol LDL Middle Aged biology.organism_classification Yogurt Cholesterol chemistry low-density lipoprotein Low-density lipoprotein Fermentation Female lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Nutrients, Vol 10, Iss 11, p 1778 (2018) Volume 10 Issue 11 |
| ISSN: | 2072-6643 |
| Popis: | In order to clarify the effects of the Lactococcus lactis (L. lactis) 11/19-B1 strain, a double-blind controlled study of yogurt fermented with the strain was carried out. For the study, two kinds of yogurt, the control and test yogurt, were prepared the control yogurt was fermented with Streptococcus thermophiles, Lactobacillus delbrueckii subspecies bulgaricus, and Lactobacillus acidophilus, and the test yogurt was enriched with L. lactis 11/19-B1 and Bifidobacterium lactis (B. lactis) BB-12 strains. Seventy-six volunteers who had not received treatment with pharmaceuticals were randomly divided into two groups with each group ingesting 80 g of either the test or control yogurt every day for 8 weeks. Before and after yogurt intake, fasting blood was taken and blood sugar, blood lipids, and anti-cytomegalovirus cellular immunity were estimated. In the test yogurt group, low-density lipoprotein (LDL) was significantly decreased (159.1 ± 25.7 to 149.3 ± 24.4 p = 0.02), but this effect was not observed in the control yogurt group. When the test yogurt group was divided into two groups based on LDL levels of over or under 120 mg/dL, this effect was only observed in the high LDL group. No LDL-lowering effect of B. lactis BB-12 strain was previously reported therefore, the hypocholesterolemic effects observed in this study are thought to be caused by the L. lactis 11/19-B1 strain alone or its combination with the B. lactis BB-12 strain. |
| Databáze: | OpenAIRE |
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