Selective vulnerability in acute energy deprivation syndromes
| Autor: | Cavanagh Jb |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Histology Encephalopathy Disease Pathology and Forensic Medicine Wernicke's encephalopathy Pathogenesis Physiology (medical) Selective vulnerability medicine Animals Humans Wernicke Encephalopathy Leigh disease business.industry Imidazoles medicine.disease Surgery Dinitrobenzenes 6-Aminonicotinamide Neurology Acute Disease Thiamine Disease Susceptibility Neurology (clinical) Leigh Disease Nervous System Diseases Energy Metabolism business Neuroscience |
| Zdroj: | Neuropathology and Applied Neurobiology. 19:461-470 |
| ISSN: | 1365-2990 0305-1846 |
| DOI: | 10.1111/j.1365-2990.1993.tb00474.x |
| Popis: | The topography and cellular events in the experimental lesions caused by chlorosugars, 6-aminonicotinamide, dinitrobenzene and tribromoimidazole in animals are considered in relation to those features in human acute thiamine deficiency (Wernicke's) encephalopathy and for comparison in Leigh's disease. The topography and cellular changes when closely examined are different and particular to each condition, although there is a basic cellular process common to all. The pathogenesis of each condition must be considered as multifactorial and a search for the factors responsible for the neuronal and cellular selective vulnerability of different regions of the neuraxis will lead us to understanding the pathogenesis of the disease process in each instance. The experimental models offer much for the understanding of the human conditions, particularly in the search for satisfactory therapeutic strategies. |
| Databáze: | OpenAIRE |
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