Effectiveness of Teriparatide in Women Over 75 Years of Age with Severe Osteoporosis: 36-Month Results from the European Forsteo Observational Study (EFOS)
| Autor: | Annabel Barrett, Franz Jakob, Fernando Marin, Gérald Rajzbaum, Astrid Fahrleitner-Pammer, Bente L. Langdahl, J. Bernard Walsh, Willem F. Lems, Östen Ljunggren, Dimitrios Karras |
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| Přispěvatelé: | Rheumatology, MOVE Research Institute, CCA - Innovative therapy |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Visual analogue scale Health-related quality of life Endocrinology Diabetes and Metabolism Osteoporosis Context (language use) Fractures Bone Age Endocrinology Quality of life Internal medicine Teriparatide Back pain Medicine Humans Orthopedics and Sports Medicine Osteoporosis Postmenopausal Aged Original Research Aged 80 and over ddc:616 Bone Density Conservation Agents business.industry Repeated measures design medicine.disease Discontinuation Logistic Models Fracture Physical therapy Quality of Life Female medicine.symptom business medicine.drug |
| Zdroj: | Calcified Tissue International, 90(5), 373-383. Springer New York Walsh, J B, Lems, W F, Karras, D, Langdahl, B L, Ljunggren, O, Fahrleitner-Pammer, A, Barrett, A, Rajzbaum, G, Jakob, F & Marin, F 2012, ' Effectiveness of Teriparatide in women over 75 years of age with severe osteoporosis : 36-month results from the European Forsteo Observational Study (EFOS) ', Calcified Tissue International, vol. 90, no. 5, pp. 373-83 . https://doi.org/10.1007/s00223-012-9590-9 Walsh, J B, Lems, W F, Karras, D, Langdahl, B L, Ljunggren, O, Fahrleitner-Pammer, A, Barrett, A, Rajzbaum, G, Jakob, F & Marin, F 2012, ' Effectiveness of Teriparatide in Women Over 75 Years of Age with Severe Osteoporosis: 36-Month Results from the European Forsteo Observational Study (EFOS) ', Calcified Tissue International, vol. 90, no. 5, pp. 373-383 . https://doi.org/10.1007/s00223-012-9590-9 Calcified Tissue International |
| ISSN: | 0171-967X |
| DOI: | 10.1007/s00223-012-9590-9 |
| Popis: | This predefined analysis of the European Forsteo Observational Study (EFOS) aimed to describe clinical fracture incidence, back pain, and health-related quality of life (HRQoL) during 18 months of teriparatide treatment and 18 months post-teriparatide in the subgroup of 589 postmenopausal women with osteoporosis aged ≥75 years. Data on clinical fractures, back pain (visual analogue scale, VAS), and HRQoL (EQ-5D) were collected over 36 months. Fracture data were summarized in 6-month intervals and analyzed using logistic regression with repeated measures. A repeated-measures model analyzed changes from baseline in back pain VAS and EQ-VAS. During the 36-month observation period, 87 (14.8 %) women aged ≥75 years sustained a total of 111 new fractures: 37 (33.3 %) vertebral fractures and 74 (66.7 %) nonvertebral fractures. Adjusted odds of fracture was decreased by 80 % in the 30 to |
| Databáze: | OpenAIRE |
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