Role of adrenals in the vitamin A-mediated increase in the activities of gluconeogenic enzymes of rat liver
| Autor: | T.A. Venkitasubramanian, Vishwa Nath Singh, Malathy Singh |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Blood Glucose
Male Vitamin medicine.medical_specialty medicine.medical_treatment Stimulation Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Oral administration Internal medicine Adrenal Glands medicine Animals General Pharmacology Toxicology and Pharmaceutics Vitamin A Pyruvate Carboxylase chemistry.chemical_classification Adrenalectomy Gluconeogenesis Alanine Transaminase General Medicine Hypervitaminosis medicine.disease Fructose-Bisphosphatase Rats Lactic acid Enzyme Activation Bicarbonates Endocrinology Enzyme Liver chemistry Glucose-6-Phosphatase Phosphoenolpyruvate Carboxykinase (GTP) |
| Zdroj: | Life Sciences. 17:859-865 |
| ISSN: | 0024-3205 |
| Popis: | Oral administration of large doses of vitamin A to rats even for two days was found to cause marked increase in the activities of PEP-carboxykinase, fructose-1, 6-diphosphatase, glucose-6-phosphatase and alanine aminotransferase in liver. However, overdosage of this vitamin failed to enhance the activities of these enzymes in the livers of bilaterally adrenalectomized rats. The adrenalectomy was also found to abolish the vitamin A-mediated increase in the levels of glucose and lactic acid in the blood. Thus, it is concluded that stimulation of gluconeogenesis in hypervitaminosis is, perhaps, caused by the increase in the activities of the key gluconeogenic enzymes of the liver, and that adrenal hormones are directly or indirectly involved in this process. |
| Databáze: | OpenAIRE |
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