Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma
| Autor: | Lilián Díaz, Stefanía López, Carolina Oliver, Raul Gabus, Victoria Irigoin, Ana Inés Landoni |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Adolescent Monocytes Leukocyte Count Young Adult International Prognostic Index Monocyte count High monocyte count Standard Risk hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols Medicine Humans Young adult Aged Retrospective Studies Aged 80 and over business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease Prognosis Lymphoma Female Immunotherapy Lymphoma Large B-Cell Diffuse business Diffuse large B-cell lymphoma |
| Zdroj: | Revista médica de Chile v.147 n.12 2019 SciELO Chile CONICYT Chile instacron:CONICYT |
| ISSN: | 0717-6163 |
| Popis: | Background Prognosis of patients with Diffuse Large B Cell Lymphoma (DLBCL) is highly variable, and despite the use of modern immunochemotherapy regimens, almost 50% of patients will eventually relapse. Standard risk models, like the International Prognostic Index or the Revised International Prognostic Index (R_IPI) incorporate patient and tumor characteristics but do not consider variables related to host adaptive immunity which have been shown to be of significant prognostic value in non-Hodgkin lymphomas. Aim To analyze the prognostic significance of the absolute monocyte count at diagnosis in diffuse large-B-cell lymphoma in a retrospective setting. Material and Methods We reviewed data of 171 patients with DLBCL treated with Rituximab-based immunochemotherapy at two reference public Hospitals in Montevideo-Uruguay. The outcome measures were overall and relapse free survival. Results The absolute monocyte count, analyzed as a dichotomized variable predicted progression-free and overall survival in low risk patients according to the R-IPI score. Worse outcomes were observed in those with high monocyte count al diagnosis. Conclusions Absolute monocyte count could help in the identification of high-risk patients otherwise expected to have a good prognosis according to traditional scores. |
| Databáze: | OpenAIRE |
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