Acute renal failure and severe hypertension in children with renal thrombotic microangiopathy
| Autor: | A. Bagga, Rajendra N. Srivastava, U. N. Bhuyan |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Hemolytic anemia
Male medicine.medical_specialty Pathology Thrombotic microangiopathy Hypertension Renal Adolescent Fluorescent Antibody Technique urologic and male genital diseases Kidney Gastroenterology Hemoglobins Internal medicine medicine Humans Child Proteinuria urogenital system business.industry Vascular disease Microcirculation Microangiopathy Thrombosis Acute Kidney Injury medicine.disease female genital diseases and pregnancy complications Uremia Immunoglobulin A medicine.anatomical_structure Child Preschool Immunoglobulin G Etiology Female medicine.symptom business Interlobular arteries |
| Zdroj: | Nephron. 66(3) |
| ISSN: | 1660-8151 |
| Popis: | We observed 12 boys and 1 girl, 5-15 years old, presenting with acute renal failure (ARF) and severe hypertension. They constituted 4.9% of all patients with ARF. There was no preceding diarrheal or respiratory prodrome. Clinical and laboratory findings were indicative of hemolytic uremic syndrome (HUS) in 4, but obscure in 9 others. Renal biopsies revealed variably severe occlusive thrombotic microangiopathy (TMA) affecting predominantly interlobular arteries in 8 and both arteries and glomeruli in 5 cases. Glomerular crescents and cortical necrosis were not seen. Following supportive therapy, 8 progressed to or died of uremia; 2 showed persistent proteinuria, 1 moderate hypertension and 2 complete recovery. Our observations indicate that renal TMA without a prodromal illness and typical features of HUS may present with ARF, proteinuria and severe hypertension, and is associated with high mortality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|