Treatment of valproic acid overdose with meropenem in an epileptic patient
| Autor: | David Cunningham, Kacie Clark, Kito Lord |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Adult
Carbapenem Antagonists & inhibitors Pharmacology Meropenem Epilepsy medicine Humans Valproic Acid business.industry Hyperammonemia General Medicine medicine.disease Anti-Bacterial Agents Carbapenems Mood disorders Toxicity Emergency Medicine Anticonvulsants Female lipids (amino acids peptides and proteins) Drug Overdose business medicine.drug |
| Zdroj: | The American Journal of Emergency Medicine. 53:284.e1-284.e3 |
| ISSN: | 0735-6757 |
| Popis: | Valproic acid (VPA) and derivatives are effective anticonvulsants that are also used for numerous mood disorders. VPA toxicity can cause central nervous system (CNS) depression, dose related hyperammonemia, and eventually hepatotoxicity. While traditional treatment of VPA toxicity often includes l -carnitine, activated charcoal, and hemodialysis; an interaction with carbapenem class antibiotics has been well established in literature and may offer a different avenue of treatment. This case describes a 38 year-old female with a past medical history of epilepsy effectively treated with meropenem to rapidly and safely lower toxic VPA levels after an acute ingestion. A review of four VPA poisoning case reports and the interaction with carbapenem class antibiotics is also included. |
| Databáze: | OpenAIRE |
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