Analysis of chemical constituents in an herbal formula Jitong Ning Tablet
| Autor: | Zhipeng Huo, Di Gao, Lian-Wen Qi, Zhidong Lei, Navaneethakrishnan Polachi, Baojun Wang, Song Zhaohui, Liu Xiaoxiao, He Yi |
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| Rok vydání: | 2017 |
| Předmět: |
Clinical Biochemistry
ved/biology.organism_classification_rank.species Pharmaceutical Science Paeonia Mass spectrometry 01 natural sciences Glycyrrhizae Radix Mass Spectrometry Analytical Chemistry Paeoniae Radix Drug Discovery Radix Chromatography High Pressure Liquid Spectroscopy Chromatography biology 010405 organic chemistry Chemistry ved/biology 010401 analytical chemistry biology.organism_classification Terpenoid 0104 chemical sciences Eucommia Chemical constituents Corydalis yanhusuo Drugs Chinese Herbal Tablets |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 140:301-312 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/j.jpba.2017.03.033 |
| Popis: | Jitong Ning Tablet (JTNT), a traditional Chinese herbal formula, consists of Eucommia ulmodies oliv, Angelicae pubescentis radix, Aconiti radix cocta, Corydalis yanhusuo w.t. wang, Glycyrrhizae radix et rhizoma, Paeoniae radix rubra and Radix puerariae. It has been demonstrated to show protective effects on ankylosing spondylitis and anti-inflammatory effects. The chemical compositions of JTNT, playing a key role in quality control, remain unknown. In this study, an ultra-performance liquid chromatography combined with quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS) method in both positive and negative ion mode was established to investigate the chemical constituents of JTNT formula. In total, 162 compounds including flavonoids, triterpenoids, coumarins, alkaloids, phenylpropionic acids, lignans, terpenoids, and organic acids were detected, 152 of which were unambiguously or tentatively identified by comparing their retention times and accurate mass measurement with reference compounds and data in literatures. Our results would benefit quality control and chemical basis for JTNT. |
| Databáze: | OpenAIRE |
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