Effectiveness of tranexamic acid for reducing intraoperative bleeding in palatoplasties: A randomized clinical trial
| Autor: | Nivaldo Alonso, Daniela Bezerra de Melo, Maria do Carmo M.B. Duarte, Rui Manoel Rodrigues Pereira, Guilherme Campelo Arantes |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Blood Loss Surgical Placebo Intraoperative bleeding law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Blood loss Randomized controlled trial Double-Blind Method 030202 anesthesiology law Statistical significance Medicine Humans Child TRANSTORNOS HEMORRÁGICOS business.industry Palate Incidence (epidemiology) Infant 030206 dentistry Antifibrinolytic Agents Surgery Cleft Palate Palatoplasty Otorhinolaryngology Tranexamic Acid Anesthesia Child Preschool Female Oral Surgery business Tranexamic acid medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1878-4119 |
| Popis: | Background Few data are available regarding blood loss during cleft palate surgery. This study assessed the effect of using tranexamic acid in the reduction of intraoperative bleeding. Methods A double-blind, randomized clinical trial compared intraoperative bleeding and the incidence of oronasal fistulas after palatoplasties in a control group that was given placebo and an intervention group that was given 10 mg/kg tranexamic acid followed by a continuous infusion of 1 mg/kg/h of the same until the end of surgery. Patients who underwent primary palatoplasty with no known or suspected coagulation disorders at our institution during the study period were included in the study. Results 70 patients were allocated, 66 received the intervention. Blood loss was reduced by 11.9%, without statistical significance. The incidence of fistulas in the intervention and control groups was 12.9% and 18.75%, respectively. The reduction of 5.8% (CI 95%: 12%–23.8%) was not significant. Conclusions The reduction of intraoperative blood loss was lower than expected and not statistically significant; a larger sample is needed to confirm the observed reduction. The drug did not seem to have negative effects on flap viability. |
| Databáze: | OpenAIRE |
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