Derivatives of GdAAZTA Conjugated to Amino Acids: A Multinuclear and Multifrequency NMR Study

Autor:	Daniela Lalli, Ivan Hawala, Marco Ricci, Fabio Carniato, Luca D. D’Andrea, Lorenzo Tei, Mauro Botta
Rok vydání:	2022
Předmět:	Inorganic Chemistry Magnetic Resonance Spectroscopy Contrast Media Humans Gadolinium Amino Acids Physical and Theoretical Chemistry Magnetic Resonance Imaging Chelating Agents
Zdroj:	Inorganic Chemistry. 61:13199-13209
ISSN:	1520-510X 0020-1669
DOI:	10.1021/acs.inorgchem.2c02110
Popis:	The GdAAZTA (AAZTA = 6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) complex represents a platform of great interest for the design of innovative MRI probes due to its remarkable magnetic properties, thermodynamic stability, kinetic inertness, and high chemical versatility. Here, we detail the synthesis and characterization of new derivatives functionalized with four amino acids with different molecular weights and charges: l-serine, l-cysteine, l-lysine, and l-glutamic acid. The main reason for conjugating these moieties to the ligand AAZTA is the in-depth study of the chemical properties in aqueous solution of model compounds that mimic complex structures based on polypeptide fragments used in molecular imaging applications. The analysis of the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99796d2c82b497990cdae59bd726cfd https://doi.org/10.1021/acs.inorgchem.2c02110 Zobrazit plný text záznamu