A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk

Autor: Castro-Quezada, Itandehui, Sanchez-Villegas, Almudena, Estruch, Ramon, Salas-Salvado, Jordi, Corella, Dolores, Schroeder, Helmut, Alvarez-Perez, Jacqueline, Dolores Ruiz-Lopez, Maria, Artacho, Reyes, Ros, Emilio, Bullo, Monica, Covas, Maria-Isabel, Ruiz-Gutierrez, Valentina, Ruiz-Canela, Miguel, Buil-Cosiales, Pilar, Gomez-Gracia, Enrique, Lapetra, Jose, Pinto, Xavier, Aros, Fernando, Fiol Sala, Miquel, Maria Lamuela-Raventos, Rosa, Angel Martinez-Gonzalez, Miguel, Serra-Majem, Lluis, PREDIMED Study Investigators
Přispěvatelé: Bioquímica i Biotecnologia, Universitat Rovira i Virgili., Universitat de Barcelona
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Gerontology
Male
Physiology
Epidemiology
modelos de riesgos proporcionales
humanos
lcsh:Medicine
Dieta mediterrània
Fats
Elderly
Risk Factors
índice glucémico
Cause of Death
Medicine and Health Sciences
Medicine
lcsh:Science
mediana edad
Aged
80 and over
education.field_of_study
anciano
Multidisciplinary
Death rates
Geography
Geographical regions
dieta
Mortality rate
Hazard ratio
Regional geography
Age Factors
Middle Aged
Glycemic index
Cardiovascular diseases
Quartile
Physiological Parameters
Cardiovascular Diseases
Female
Dieta
Research Article
medicine.medical_specialty
Population
Carbohydrates
enfermedades cardiovasculares
Blood sugar
National Death Index
causas de muerte
Internal medicine
Glycemic load
Dietary Carbohydrates
Mortalitat
Humans
factores de riesgo
Obesity
Fatty acids
Mortality
education
Cardiovascular Disease Epidemiology
Glycemic
Nutrition
Aged
Proportional Hazards Models
conducta alimentaria
business.industry
Physical activity
carbohidratos dietéticos
Malalties cardiovasculars
lcsh:R
Body Weight
Biology and Life Sciences
PREDIMED study
Nutrients
Feeding Behavior
Genitourinary cancers
Diet
Earth sciences
Glucèmia
Geriatrics
Glycemic Index
lcsh:Q
Mediterranean Basin
business
human activities
Zdroj: Plos One
PLoS ONE
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE, Vol 9, Iss 9, p e107968 (2014)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Recercat. Dipósit de la Recerca de Catalunya
Dadun. Depósito Académico Digital de la Universidad de Navarra
Repositori Universitat Jaume I
Universitat Jaume I
Digital.CSIC. Repositorio Institucional del CSIC
Repositori Institucional de la Universitat Rovira i Virgili
Universitat Rovira i virgili (URV)
DOI: 10.1371/journal.pone.0107968
Popis: © 2014 Castro-Quezada et al. Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this study was to estimate the association between dietary GI and GL and risk of all-cause mortality in the PREDIMED study. Material and Methods: The PREDIMED study is a randomized nutritional intervention trial for primary cardiovascular prevention based on community-dwelling men and women at high risk of cardiovascular disease. Dietary information was collected at baseline and yearly using a validated 137-item food frequency questionnaire (FFQ). We assigned GI values of each item by a 5-step methodology, using the International Tables of GI and GL Values. Deaths were ascertained through contact with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) and their 95% CI for mortality, according to quartiles of energy-adjusted dietary GI/GL. To assess repeated measures of exposure, we updated GI and GL intakes from the yearly FFQs and used Cox models with time-dependent exposures. Results: We followed 3,583 non-diabetic subjects (4.7 years of follow-up, 123 deaths). As compared to participants in the lowest quartile of baseline dietary GI, those in the highest quartile showed an increased risk of all-cause mortality [HR =2.15 (95% CI: 1.15-4.04); P for trend =0.012]. In the repeated-measures analyses using as exposure the yearly updated information on GI, we observed a similar association. Dietary GL was associated with all-cause mortality only when subjects were younger than 75 years. Conclusions: High dietary GI was positively associated with all-cause mortality in elderly population at high cardiovascular risk.
This report has been supported by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through grants provided to research networks specifically developed for the trial [RTIC G03/140, to R E; RTIC RD 06/0045, to MA M-G] and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn); Centro Nacional de Investigaciones Cardiovasculares [CNIC 06/2007]; Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional [PI04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, and P11/02505]; Ministerio de Ciencia e Innovación [AGL-2009-13906-C02 and AGL2010-22319-C03]; Fundación Mapfre 2010; Agencia Canaria de Investigación, Innovación y Sociedad de la Información-EU FEDER [PI 2007/050]; Consejería de Salud de la Junta de Andalucía [PI0105/2007]; Public Health Division of the Department of Health of the Autonomous Government of Catalonia; Generalitat Valenciana [ACOMP06109, GVACOMP2010-181, GVACOMP2011-151, CS2010-AP-111, and CS2011-AP-042]; Regional Government of Navarra [P27/2011] and IC-Q is supported by a scholarship of the Consejo Nacional de Ciencia y Tecnología de México (National Council on Science and Technology of México, CONACYT). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Databáze: OpenAIRE
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