Gastroprotective effect of mature silkworm, Bombyx mori against ethanol-induced gastric mucosal injuries in rats
| Autor: | Kyung-Sook Hong, Jong-Gon Son, Sun-Mi Yun, Sang-Deok Ji, Jae-Min Cho, Da-Young Lee, Eun-Hee Kim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Normal diet Medicine (miscellaneous) Pharmacology 03 medical and health sciences chemistry.chemical_compound Anti-oxidation 0302 clinical medicine Immune system Bombyx mori Anti-inflammation medicine Gastric mucosa TX341-641 Secretion Nutrition and Dietetics Ethanol biology Nutrition. Foods and food supply business.industry Gastric ulcer fungi biology.organism_classification Mucus digestive system diseases Surgery 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Mature silkworm powder Gastritis medicine.symptom business Food Science |
| Zdroj: | Journal of Functional Foods, Vol 39, Iss, Pp 279-286 (2017) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2017.10.036 |
| Popis: | Gastric ulcer is a clinical condition characterized by ulceration of the surface of the gastric mucosa. Alcohol consumption has been identified as a major cause of gastric ulceration. The silkworm, Bombyx mori, produces diverse functional materials including silk proteins. Here, we evaluated whether Steamed and freeze-dried Mature Silkworm larval Powder (SMSP) can prevent ethanol-induced gastric injury in rats. Sprague-Dawley rats pretreated with SMSP (0.1 or 1 g/kg body weight) or normal diet (AIN-76A) were subjected to intragastric administration of absolute ethanol (3 g/kg body weight, 3 h). Pretreatment with SMSP significantly prevented ethanol-induced gastric mucosal ulceration and hemorrhagic injury, by which improved the total antioxidant capacity and mucus secretion and suppressed the pro-inflammatory responses through inhibiting the recruitment of immune cells. SMSP exerted protective effects in ethanol-induced gastritis via the regulation of anti-oxidative and pro-inflammatory signaling pathway, suggesting SMSP could be anticipating remedy for the treatment of ethanol-induced gastric injury. |
| Databáze: | OpenAIRE |
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