Combined analysis of whole blood interferon gamma release assay and complete blood count analysis for rapid discrimination of active tuberculosis and latent tuberculosis infection
| Autor: | Yong Sung Lee, Junseong Kim, Sunghyun Kim, Heechul Park, Sung-Bae Park, Sunyoung Park, Yun-Jeong Kang, Jungho Kim, Jiyoung Lee |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Pulmonary and Respiratory Medicine medicine.medical_specialty Tuberculosis 030106 microbiology Population Interferon gamma release assay White blood cell differential count Tuberculin Infectious and parasitic diseases RC109-216 Article Mycobacterium tuberculosis Diseases of the respiratory system 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Latent tuberculosis infection 030212 general & internal medicine education Whole blood education.field_of_study RC705-779 biology medicine.diagnostic_test Latent tuberculosis business.industry Complete blood count Biomarker biology.organism_classification medicine.disease bacterial infections and mycoses Active tuberculosis Infectious Diseases business |
| Zdroj: | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 24, Iss, Pp 100253-(2021) |
| ISSN: | 2405-5794 |
| Popis: | Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (MTB), is a serious infectious disease with high infection and mortality rates and is a public health problem around the world. According to the World Health Organization (WHO) report, one-third of the world's population is latently infected with MTB, and 5 to 10% of those with latent TB infection (LTBI) have the potential to develop active TB once in their lifetime. Therefore, TB management for promptly distinguishing LTBI from active TB and for proper treatment is important. LTBI is currently diagnosed using the tuberculin skin test (TST) and interferon gamma (IFN-γ) release assay (IGRA). However, this test is substantially limited by its inability to distinguish active TB from LTBI. It is necessary to discover indicators that can be used for effective TB management and to develop diagnostic methods. In the present study, we used IGRA and complete blood count (CBC) analysis for discrimination of active TB, LTBI, and healthy control groups. The results showed that the number of WBC was significantly increased in the group with active TB (p |
| Databáze: | OpenAIRE |
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