Selective intra-lysosomal concentration of niobium in kidney and bone marrow cells: a microanalytical study
| Autor: | P. Galle, Berry Jp, F. Bertrand |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Niobium chemistry.chemical_element Bone Marrow Cells Kidney General Biochemistry Genetics and Molecular Biology Phosphates Biomaterials Bone Marrow Lysosome Microscopy medicine Animals Rats Wistar Organelles Chemistry Metals and Alloys Kidney metabolism Rats Crystallography medicine.anatomical_structure Transmission electron microscopy Biophysics Bone marrow Lysosomes General Agricultural and Biological Sciences Electron Probe Microanalysis Lumen (unit) |
| Zdroj: | Biometals. 6 |
| ISSN: | 1572-8773 0966-0844 |
| Popis: | Niobium is used as an alloy in the industrial and biomedical fields. The concentration of the toxic element in organs of a number of animal species has been defined by using radioactive niobium (95Nb). However, tissue lesions induced by niobium have only been studied at the light microscopy level. In this study, we used an electron probe X-ray analyzer equipped with a transmission electron microscope to define the localization of this element in kidney and bone marrow cells. Results demonstrated that niobium is located in the lysosome and that this element coprecipitates with phosphate. In kidney, lysosomes and precipitates are eliminated in the tubular lumen. In contrast, precipitates appear to be eliminated more slowly from the lysosomes of bone marrow macrophages. These processes therefore correspond to one of the mechanisms by which lysosomes eliminate certain toxic mineral elements and thus play a role in the more general process of the body's defenses. |
| Databáze: | OpenAIRE |
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