Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study
| Autor: | Karin Broberg, Tanzy Love, Gary J. Myers, Katherine Grzesik, Maria S. Mulhern, J. J. Strain, Philip W. Davidson, Conrad F. Shamlaye, Alison J. Yeates, Tristram Smith, Gene E. Watson, Edwin van Wijngaarden, Jessica L. Irwin, Emeir M. McSorley, Sally W. Thurston |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Offspring Immunology Immune markers medicine.disease_cause Third trimester Seychelles Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Child Development Pregnancy medicine Immunology and Allergy Humans Inflammation Human studies business.industry Obstetrics Infant Immune dysregulation medicine.disease Child development 030104 developmental biology Neurology Prenatal Exposure Delayed Effects Gestation Female Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | J Neuroimmunol |
| ISSN: | 1872-8421 |
| Popis: | Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1,453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings. |
| Databáze: | OpenAIRE |
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