Stimulation of Ribonucleic Acid Polymerase Activity in Mouse Kidney*
| Autor: | Sharon M. Ventura, L P Bullock |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Medroxyprogesterone
Receptors Steroid medicine.medical_specialty medicine.drug_class Antiandrogens Biology Kidney Flutamide Mice chemistry.chemical_compound Endocrinology RNA Polymerase I Internal medicine medicine RNA polymerase I Animals Medroxyprogesterone acetate Testosterone Cyproterone Cyproterone Acetate Progesterone Cyproterone acetate DNA-Directed RNA Polymerases Mice Inbred C57BL Androgen receptor chemistry Receptors Androgen Female RNA Polymerase II Progestin medicine.drug |
| Zdroj: | Endocrinology. 112:567-572 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-112-2-567 |
| Popis: | As part of an ongoing study to determine the mechanisms that differentiate between the agonistic and antagonistic effects of steroids, several natural and synthetic compounds that bind to the androgen receptor were evaluated for their effects on renal nuclear RNA polymerase I and II activities. The androgenic progestin 6α-methyl-progesterone (6MP) as well as the antiandrogens cyproterone acetate (6-chloro-17α-acetoxyl-l,2α-methylene-4,6-pregnadiene-3,20-dione) and flutamide (4′-nitro-3′-trifluoromethylisobutyrylanilide) and ineffective steroids 17α-hydroxy-6MP and progesterone were studied using normal and Tfm/Y mice, which lack effective androgen receptors. In normal mice, a single dose of 6MP stimulated a biphasic pattern of early (30 min) and late (16–24 h) increases in the activities of RNA polymerase I and II, which was similar to the responses induced by testosterone and medroxyprogesterone acetate (6α-methyl-17α-acetoxy-4-pregnene-3,20-dione). Cyproterone acetate stimulated an early increase in pol... |
| Databáze: | OpenAIRE |
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