Efficacy and safety of ombitasvir/paritaprevir/ritonavir and dasabuvir with low‐dose ribavirin in patients with chronic hepatitis C virus genotype 1a infection without cirrhosis

Autor:	Roger Trinh, Akshanth R. Polepally, Natarajan Ravendhran, Leslie Bank, Paul J. Pockros, Robert Reindollar, Fred Poordad, Marisol Martinez, Michael S. Epstein, David E. Bernstein, David R. Nelson, Shahriar Sedghi, Michael R. Lucey, Preethi Krishnan, Kristina Unnebrink
Rok vydání:	2019
Předmět:	hepatitis C virus low‐dose ribavirin Cyclopropanes Male Hepacivirus medicine.disease_cause Gastroenterology GEODE‐II chemistry.chemical_compound 0302 clinical medicine interferon‐free therapy 2-Naphthylamine Anilides 030212 general & internal medicine Sulfonamides Dasabuvir virus diseases Valine Treatment Outcome Infectious Diseases Tolerability Drug Therapy Combination Female 030211 gastroenterology & hepatology medicine.drug medicine.medical_specialty Macrocyclic Compounds Drug-Related Side Effects and Adverse Reactions Genotype Proline Short Communication Lactams Macrocyclic Hepatitis C virus Antiviral Agents Drug Administration Schedule 03 medical and health sciences Virology Internal medicine Ombitasvir/paritaprevir/ritonavir Ribavirin medicine Humans Uracil Ritonavir Hepatology business.industry Hepatitis C Chronic genotype 1a Ombitasvir chemistry Paritaprevir Carbamates business
Zdroj:	Journal of Viral Hepatitis
ISSN:	1365-2893 1352-0504
DOI:	10.1111/jvh.13109
Popis:	Patients infected with hepatitis C virus (HCV) treated with interferon‐free direct‐acting antivirals may still require ribavirin. However, ribavirin is associated with adverse events that can limit its use. This open‐label, multicentre, Phase 3 study evaluated the safety and efficacy of ombitasvir/paritaprevir/ritonavir + dasabuvir (OBV/PTV/r + DSV) with low‐dose ribavirin for 12 weeks in genotype 1a‐infected patients without cirrhosis. The primary efficacy endpoint was sustained virologic response at post‐treatment Week 12 (SVR12). The primary safety endpoint was haemoglobin
Databáze:	OpenAIRE
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