Variation of choline-substituted lipid metabolism in doxorubicin-resistant leukemia cells
| Autor: | G Dubois, H Tapiero |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Phospholipid
In Vitro Techniques Biology Mice chemistry.chemical_compound hemic and lymphatic diseases Tumor Cells Cultured medicine Membrane fluidity Animals Humans Choline skin and connective tissue diseases Pharmacology Phosphatidylethanolamine Leukemia Leukemia Experimental Phosphatidylethanolamines Drug Resistance Microbial Lipid metabolism General Medicine medicine.disease carbohydrates (lipids) Sphingomyelin Phosphodiesterase chemistry Biochemistry Doxorubicin Phosphatidylcholines sense organs Sphingomyelin K562 cells |
| Zdroj: | Biomedicine & Pharmacotherapy. 46:485-489 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/0753-3322(92)90006-s |
| Popis: | In adriamycin-resistant murine (FLC) and human (K562) leukemia cells, phosphatidyicholine increases and phosphatidylethanolamine decreases compared to adriamycin-sensitive lines. This change is due to an increase in phosphatidylethanolamine methylation. The choline pathway of phosphatidyicholine biosynthesis is also disturbed in resistant cells with a blocking step of CDP-phosphocholine transferase and a decrease in sphingomyelinase activity. These changes in phospholipid metabolism are suggested to be responsible for the changes in membrane fluidity reported previously (Tapiero et al , 1986) for resistant cells. phosphatidyicholine / sphingomyelin / MDR + leukemia cells |
| Databáze: | OpenAIRE |
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