First-in-man dose escalation and pharmacokinetic study of CAP7.1, a novel prodrug of etoposide, in adults with refractory solid tumours
| Autor: | V. Kümmerlen, P. Mehlitz, L. Rohde, N. Utku, M. Knoedler, M. Machacek, M. Lassus, P. Treasure, Glyn B. Steventon, Konrad Klinghammer, Alexander Schmittel, U. Keilholz |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology Cancer Research medicine.medical_specialty Maximum Tolerated Dose Nausea Pharmacology 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Refractory Neoplasms Internal medicine medicine Humans Prodrugs Etoposide Aged Dose-Response Relationship Drug business.industry Middle Aged Prodrug medicine.disease 030104 developmental biology Tolerability 030220 oncology & carcinogenesis Toxicity Female medicine.symptom business Febrile neutropenia medicine.drug |
| Zdroj: | European Journal of Cancer. 80:14-25 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2017.03.032 |
| Popis: | Aim An open-label, phase I dose-escalation trial was performed in adult patients with various solid cancers to identify the maximum tolerated dose (MTD), to assess the safety, pharmacokinetic profile and anti-tumour activity of the new prodrug CAP7.1. The prodrug is converted to its active moiety etoposide via carboxylesterases in selective cells leading to a better tolerability and higher efficacy in therapeutic resistance cells and children with refractory neuroblastoma. Patients and methods Eligible adult patients with advanced, refractory, solid malignancies received CAP7.1 as intravenous infusion on 5 consecutive days. Doses were escalated in four cohorts consisting of three to six patients, with a starting dose of 45 mg/m2/day. Treatment cycles were repeated in 21-day intervals in the absence of disease progression and prohibitive toxicity. The safety, pharmacokinetics and efficacy were evaluated, and the MTD and dose-limiting toxicity (DLT) were determined. Results Nineteen patients were assigned to four CAP7.1 dose cohorts (45, 90, 150 and 200 mg/m2/day). CAP7.1 was well tolerated. Haematotoxicity was observed at the two highest dose levels including three DLTs (two febrile neutropenia and one sepsis) only and were reversible with adequate therapy. No organ toxicity was observed. Non-haematological toxicities (mild-moderate) consist mainly of nausea, fatigue, vomiting, pyrexia and alopecia. One partial response and 11 stable diseases were observed as supporting signs of efficacy. Conclusion MTD of CAP7.1 was reached at the dose of 200 mg/m2. A favourable safety profile and initial anti-tumour efficacy of CAP7.1 in therapeutic refractory tumours warrant further evaluation in clinical studies. |
| Databáze: | OpenAIRE |
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