Digital therapeutics for essential hypertension using a smartphone application: A randomized, open‐label, multicenter pilot study
| Autor: | Eisuke Hida, Tomoyuki Tanigawa, Shin Suzuki, Akihiro Nomura, Noriko Harada, Kohta Satake, Kazuomi Kario, Ayaka Kato, Ryuhei So |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty hypertension Ambulatory blood pressure Endocrinology Diabetes and Metabolism Blood Pressure Pilot Projects Disease 030204 cardiovascular system & hematology Essential hypertension 03 medical and health sciences 0302 clinical medicine Lifestyle modification Internal medicine Internal Medicine Clinical endpoint Humans Medicine 030212 general & internal medicine Risk factor Antihypertensive Agents Morning Original Paper digital therapeutic business.industry Blood Pressure Monitoring Ambulatory mobile application medicine.disease Mobile Applications home blood pressure monitoring ambulatory blood pressure monitoring Blood pressure Digital Health lifestyle modification Smartphone Essential Hypertension Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Clinical Hypertension |
| ISSN: | 1751-7176 1524-6175 |
| DOI: | 10.1111/jch.14191 |
| Popis: | Hypertension is the most considerable but treatable risk factor for cardiovascular disease. Although physicians prescribe multiple antihypertensive drugs and promote lifestyle modifications, the real‐world blood pressure (BP) control rate remains poor. To improve BP target achievement, we developed a novel digital therapeutic—the HERB software system —to manage hypertension. Here, we performed a randomized pilot study to assess the safety and efficacy of the HERB system for hypertension. We recruited 146 patients with essential hypertension from March 2018 to March 2019. We allocated eligible patients to the intervention group (HERB system + standard lifestyle modification) or control group (standard lifestyle modification alone). The primary outcome was the mean change from baseline to 24 weeks in 24‐hour systolic BP (SBP) measured by ambulatory blood pressure monitoring (ABPM). The baseline characteristics in each group were well balanced; the mean age was approx. 57 years, and 67% were male. In the primary end point at 24 weeks, HERB intervention did not lower the mean change of 24‐hour SBP by ABPM compared with the controls (adjusted difference: −0.66 mmHg; p = .78). In an exploratory analysis focusing on antihypertensive drug‐naïve patients aged |
| Databáze: | OpenAIRE |
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