Serum Carboxypeptidase N1 Serves as a Potential Biomarker Complementing CA15-3 for Breast Cancer
| Autor: | Ranliang Cui, Yueguo Li, Chaomin Wang, Qi Zhao, Yichao Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
CA15-3 Adult Cancer Research medicine.medical_specialty Breast Neoplasms Metastasis 03 medical and health sciences Young Adult 0302 clinical medicine Breast cancer Quality of life Internal medicine medicine Biomarkers Tumor Humans Lysine Carboxypeptidase Stage (cooking) 030304 developmental biology Aged Pharmacology 0303 health sciences business.industry Incidence (epidemiology) Mucin-1 Middle Aged medicine.disease Metastatic breast cancer 030220 oncology & carcinogenesis Potential biomarkers Molecular Medicine Female business |
| Zdroj: | Anti-cancer agents in medicinal chemistry. 20(17) |
| ISSN: | 1875-5992 |
| Popis: | Background: The incidence and mortality of breast cancer are increasing annually. Breast cancer seriously threatens women's health and quality of life. We aimed to measure the clinical value of CPN1, a new serum marker of breast cancer and to evaluate the efficacy of CPN1 in combination with CA15-3. Methods: Seventy samples of breast cancer with lymph node metastasis, seventy-three samples of nonmetastatic breast cancer and twenty-five samples of healthy human serum were collected. Serum CA15-3 concentration was determined by Roche Elecsys, and serum CPN1 concentration was determined by ELISA. Results: In breast cancer patients, serum CPN1 concentration was positively correlated with tumour size, clinical stage and CA15-3 concentration (r = 0.376, PCA15-3=0.702 vs. AUCCPN1=0.886, PCA15-3=0.629 vs. AUCCPN1=0.887, PCA15-3+CPN1=0.916) and for distinguishing between metastatic and non-metastatic breast cancer (AUCCA15-3+CPN1=0.895). Conclusion: CPN1 can be used as a new tumour marker to diagnose and evaluate the invasion and metastasis of breast cancer. The combined detection of CPN1 and CA15-3 is more accurate and has a certain value in clinical application. |
| Databáze: | OpenAIRE |
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