An abnormal ProC Global test result is associated with an increased risk of venous thromboembolism independent of test sensitivity for protein C pathway abnormalities
| Autor: | Raphaël Adda, Patricia Perez, Pierre Toulon, Jocelyn Rapp |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Pathology Test sensitivity Sensitivity and Specificity Gastroenterology Thromboembolism Internal medicine medicine Factor V Leiden Humans Risk factor Aged Venous Thrombosis Factor VIII Vascular disease business.industry Hematology Middle Aged medicine.disease Venous thrombosis Increased risk Female Blood Coagulation Tests Reagent Kits Diagnostic business Venous thromboembolism Protein C medicine.drug |
| Zdroj: | Thrombosis and Haemostasis. 98:228-233 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th05-06-0418 |
| Popis: | SummaryThe ProC® Global assay is a clotting assay primarily developed to globally evaluate the functionality of the protein C (PC) pathway. It was shown to lack both sensitivity and specificity for PC pathway abnormalities, i.e. factor V Leiden mutation, PC and PS deficiency. The hypothesis that an abnormal test result could be associated with venous thromboembolism (VTE) was evaluated in a case-control study. The proportion of reduced response was significantly higher in cases than in controls [n=71/139 (51.1%) vs. n=28/147 (19.0%); p |
| Databáze: | OpenAIRE |
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