Evidence that striatal synthesis-inhibiting autoreceptors are dopamine D3 receptors
| Autor: | Daryl A. Basham, Emanuel Meller, Menek Goldstein, Karen Bohmaker |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Apomorphine Quinelorane Dopamine Agents Receptors Dopamine Levodopa Rats Sprague-Dawley Quinpirole 4-Butyrolactone Dopamine receptor D3 Dopamine Internal medicine medicine Animals Receptor Pharmacology Dose-Response Relationship Drug Receptors Dopamine D2 Chemistry Receptors Dopamine D3 Stereoisomerism Corpus Striatum Rats Endocrinology Dopamine receptor Quinolines Autoreceptor medicine.drug |
| Zdroj: | European Journal of Pharmacology. 249:R5-R6 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(93)90674-7 |
| Popis: | The activation constants (KA; dose required to occupy 50% of receptors) for reversal of gamma-butyrolactone (GBL)-induced elevation of striatal L-3,4-dihydroxyphenylalanine (L-DOPA) levels via stimulation of presynaptic dopamine receptors were determined for apomorphine and two dopamine D3 receptor-selective agonists, quinpirole and LY163502 (quinelorane). The KA values correlated significantly with the affinities (Ki) of the agonists for the D3 (r = 0.999, P0.05) but not the D2 (r = -0.13) receptor, suggesting that striatal synthesis-inhibiting autoreceptors are of the D3 rather than the D2 subtype. |
| Databáze: | OpenAIRE |
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