Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study

Autor: Ilan Green, Eugene Merzon, Avivit Golan Cohen, Dmitry Tworowski, Alessandro Gorohovski, Milana Frenkel Morgenstern, Shlomo Vinker
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Biochemistry
Gastroenterology
Severity of Illness Index
Body Mass Index
0302 clinical medicine
Risk Factors
Odds Ratio
Prevalence
Medicine
Israel
Vitamin D
Child
Aged
80 and over
risk of infection
Univariate analysis
medicine.diagnostic_test
Age Factors
Middle Aged
Hospitalization
030220 oncology & carcinogenesis
Child
Preschool
Population study
Female
Original Article
Adult
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Adolescent
vitamin D deficiency
03 medical and health sciences
COVID‐19
Internal medicine
Vitamin D and neurology
Blood test
Humans
low plasma 25(OH) vitamin D level
Risk factor
Molecular Biology
Pandemics
Aged
business.industry
SARS-CoV-2
Israeli population study
COVID-19
Infant
Cell Biology
Odds ratio
Original Articles
medicine.disease
Vitamin D Deficiency
Confidence interval
030104 developmental biology
Social Class
business
Zdroj: The Febs Journal
The FEBS Journal
ISSN: 1742-4658
Popis: AimTo evaluate associations of plasma 25(OH)D status with the likelihood of coronavirus disease (COVID-19) infection and hospitalization.MethodsThe study population included the 14,000 members of Leumit Health Services who were tested for COVID-19 infection from February 1stto April 30th2020, and who had at least one previous blood test for plasma 25(OH)D level. “Suboptimal” or “low” plasma 25(OH)D level was defined as plasma 25-hydroxyvitamin D, or 25(OH)D, concentration below 30 ng/mL.ResultsOf 7,807 individuals, 782 (10.1%) were COVID-19-positive, and 7,025 (89.9%) COVID-19-negative. The mean plasma vitamin D level was significantly lower among those who tested positive than negative for COVID-19 [19.00 ng/mL (95% confidence interval [CI] 18.41-19.59)vs. 20.55 (95% CI 20.32-20.78)]. Univariate analysis demonstrated an association between low plasma 25(OH)D level and increased likelihood of COVID-19 infection [crude odds ratio (OR) of 1.58 (95% CI 1.24-2.01, pConclusionLow plasma 25(OH)D level appears to be an independent risk factor for COVID-19 infection and hospitalization.
Databáze: OpenAIRE
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