A selenium supplement associated or not with vitamin E delays early renal lesions in experimental diabetes in rats
| Autor: | Christelle Douillet, Muriel Bost, Françoise Borson-Chazot, Alain Tabib, Michèle Accominotti, Maryvonne Ciavatti |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.medical_treatment Kidney Glomerulus chemistry.chemical_element General Biochemistry Genetics and Molecular Biology Streptozocin Diabetes Mellitus Experimental Rats Sprague-Dawley Selenium Internal medicine Diabetes mellitus medicine TBARS Animals Vitamin E Diabetic Nephropathies Tocopherol Diminution Chemistry Insulin Organ Size medicine.disease Rats Endocrinology Food Fortified Experimental diabetes |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 211(4) |
| ISSN: | 0037-9727 |
| Popis: | Seventy rats were separated into five groups: one group of 12 was used as a control and received a purified diet, and four groups of streptozotocin-induced diabetic rats, totalling 58, were fed the same diet without or with selenium (Se) supplementation. Of the noncontrol rats, 14 were without supplementation (Group D), 14 were fed a Se-rich yeast diet (i.e., selenion) (Group DSel), 14 received selenomethionine (Group DSm), and 16 received selenomethionine + tocopherol acetate (Group DSmE). Supplementation with Se in all groups was 0.99 micromole/100g of diet and with tocopherol acetate was 0.145 micromole/100 g. All diabetic rats were mildly balanced by insulin. After 24 weeks of diet, plasma glucose tended to decrease in diabetic Se-supplemented groups DSmE > DSm > DSel versus Group D. In DSm and DSmE groups, plasma lipid peroxides also decreased compared with Group D, but this decrease reached significance only for DSmE (P < 0.01 for both TBARS and conjugated dienes). Plasma triglycerides also decreased in DSm and DSmE groups versus Group D (P < 0.01; P < 0.05, respectively). At the same time, Se increased significantly in kidneys of Groups DSel and DSm versus D and more weakly in Group DSmE, but in this case was associated with a large increase of vitamin E. These beneficial effects of selenium supplement and more so of selenium combined with vitamin E were associated with a protection of kidneys in diabetic rats which found expression in a significant correction of renal hyperfiltration (P < 0.05) and in a diminution of the number and severity of glomerular lesions (P < 0.0005). |
| Databáze: | OpenAIRE |
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