The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases
| Autor: | Doina Ganea, Kirsten M. Hooper, Weimin Kong |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Physiology
T-Lymphocytes animal diseases Vasoactive intestinal peptide Neuropeptide chemical and pharmacologic phenomena Endogeny Inflammation Biology Article Autoimmune Diseases Immune system medicine Animals Humans Innate immune system Neuropeptides Direct effects biochemical phenomena metabolism and nutrition medicine.anatomical_structure Peripheral nervous system Immunology Receptors Vasoactive Intestinal Peptide bacteria medicine.symptom hormones hormone substitutes and hormone antagonists Vasoactive Intestinal Peptide |
| Zdroj: | Acta Physiologica. 213:442-452 |
| ISSN: | 1748-1708 |
| DOI: | 10.1111/apha.12427 |
| Popis: | Neuropeptides represent an important category of endogenous contributors to the establishment and maintenance of immune deviation in the immune-privileged organs such as the CNS and in the control of acute inflammation in the peripheral immune organs. Vasoactive intestinal peptide (VIP) is a major immunoregulatory neuropeptide widely distributed in the central and peripheral nervous system. In addition to neurones, VIP is synthesized by immune cells which also express VIP receptors. Here, we review the current information on VIP production and VIP-receptor-mediated effects in the immune system, the role of endogenous and exogenous VIP in inflammatory and autoimmune disorders and the present and future VIP therapeutic approaches. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text