Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP×PS1 mice using MRI
| Autor: | Michael F. James, Simon T. Bate, Satheesh Maheswaran, Andreas Pohlmann, Derek L. G. Hill, Daniel Rueckert, Lorna Tilling, Sean C. Smart, Neil Upton, David R. Howlett, Jo Hajnal, Thomas Hartkens, Hervé Barjat, Jill C. Richardson |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Central nervous system Mice Transgenic Biology Corpus callosum White matter Amyloid beta-Protein Precursor Mice Species Specificity Alzheimer Disease Presenilin-1 medicine Animals Gliosis Longitudinal Studies Transgenes Cognitive decline Molecular Biology General Neuroscience Fornix Brain Amyloidosis medicine.disease Immunohistochemistry Magnetic Resonance Imaging Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Cerebral cortex Brain size Disease Progression Neurology (clinical) Alzheimer's disease Developmental Biology |
| Zdroj: | Brain Research. 1270:19-32 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2009.02.045 |
| Popis: | In humans, mutations of amyloid precursor protein (APP) and presenilins (PS) 1 and 2 are associated with amyloid deposition, brain structural change and cognitive decline, like in Alzheimer's disease (AD). Mice expressing these proteins have illuminated neurodegenerative disease processes but, unlike in humans, quantitative imaging has been little used to systematically determine their effects, or those of normal aging, on brain structure in vivo. Accordingly, we investigated wildtype (WT) and TASTPM mice (expressing human APP(695(K595N, M596L)) x PS1(M146V)) longitudinally using MRI. Automated global and local image registration, allied to a standard digital atlas, provided pairwise segmentation of 13 brain regions. We found the mature mouse brain, unlike in humans, enlarges significantly from 6-14 months old (WT 3.8+/-1.7%, mean+/-SD, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect