Identification of a Point Mutation in the para-Type Sodium Channel Gene from a Pyrethroid-Resistant Cattle Tick
| Autor: | Haiqi He, John E. George, Ronald B. Davey, G. W. Ivie, Andrew C. Chen |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Insecticides
DNA Complementary Molecular Sequence Data Biophysics Tick Polymerase Chain Reaction Biochemistry Sodium Channels Insecticide Resistance chemistry.chemical_compound Ticks Complementary DNA Pyrethrins parasitic diseases Animals Point Mutation Amino Acid Sequence Batrachotoxins Molecular Biology Gene Conserved Sequence Genetics Pyrethroid biology Acaricide Sodium channel Point mutation fungi Sequence Analysis DNA Cell Biology biology.organism_classification chemistry Mutation (genetic algorithm) Sequence Alignment |
| Zdroj: | Biochemical and Biophysical Research Communications. 261:558-561 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1999.1076 |
| Popis: | To investigate the molecular mechanism of resistance to pyrethroids in the southern cattle tick, Boophilus microplus, we have obtained and sequenced a partial para-homologous sodium channel cDNA from susceptible and pyrethroid-resistant tick strains. A point mutation that results in an amino acid change from Phe to Ile was identified in the highly conserved domain IIIS6 of the homologous sodium channel from ticks that are highly resistant to pyrethroid acaricides. This mutation is at a location different from those reported in the same gene in pyrethroid-resistant insects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect