Vti Proteins
| Autor: | Javier Emperador-Melero, Ruud F. Toonen, Matthijs Verhage |
|---|---|
| Přispěvatelé: | Functional Genomics, Amsterdam Neuroscience - Cellular & Molecular Mechanisms |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
SNARE proteins secretory vesicle Synaptic vesicle Synaptic Transmission Exocytosis 03 medical and health sciences symbols.namesake 0302 clinical medicine Animals Humans Secretion Neurons Chemistry General Neuroscience Vesicle Lipid bilayer fusion Golgi apparatus Qb-SNARE Proteins Secretory Vesicle Cell biology dense core vesicle Protein Transport 030104 developmental biology symbols vesicle biogenesis Lysosomes exocytosis 030217 neurology & neurosurgery Intracellular |
| Zdroj: | Neuroscience, 420, 32-40. Elsevier Limited Emperador-Melero, J, Toonen, R F & Verhage, M 2019, ' Vti Proteins : Beyond Endolysosomal Trafficking ', Neuroscience, vol. 420, pp. 32-40 . https://doi.org/10.1016/j.neuroscience.2018.11.014 |
| ISSN: | 1873-7544 0306-4522 |
| Popis: | Vti proteins are conserved from yeast to humans and regulate intracellular membrane trafficking by providing one specific SNARE domain, the Qb SNARE, to the four helical SNARE bundle that drives membrane fusion. Two mammalian Vti genes, Vti1a and Vti1b are reported to regulate distinct aspects of endolysosomal trafficking and retrograde transport to the Golgi, but have also been implicated in synaptic vesicle secretion. In this review, we summarize the current evidence for the role of Vti proteins in intracellular trafficking in different cells. We propose that, despite some unique aspects, the two mammalian VTI genes have largely redundant functions in neurosecretory cells and recycle molecules required for the sorting of regulated cargo to the Golgi. Defects in this recycling also lead to defects in synaptic transmission and dense core vesicle secretion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect