Altered serum Zinc and Copper in Iranian Adults who were of normal weight but metabolically obese
| Autor: | Ameneh Timar, Amir Hooshang Mohammadpour, Hamideh Moalemzadeh Haghighi, Zahra Khashyarmanesh, Majid Ghayour-Mobarhan, Narges Fereydouni, Susan Darroudi, Habibollah Esmaily, Fatemeh Sadabadi, Maryam Tayefi, Seyed Javad Hoseini, Batool Tayefi, Gordon A. Ferns, Kayhan Gonoodi |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Epidemiology lcsh:Medicine chemistry.chemical_element 030209 endocrinology & metabolism Zinc Article Body Mass Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine Odds Ratio medicine Humans Obesity 030212 general & internal medicine Risk factor lcsh:Science Dyslipidaemias Metabolic Syndrome Multidisciplinary business.industry lcsh:R Body Weight Odds ratio Middle Aged medicine.disease Logistic Models Endocrinology chemistry Cohort lcsh:Q Female Metabolic syndrome business Body mass index Copper Cohort study |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-51365-9 |
| Popis: | Metabolically obese normal weight (MONW) individuals are potentially at increased risk of developing metabolic syndrome. Serum zinc and copper concentrations were assessed in individuals with MONW to determine whether MONW is associated with altered serum zinc and/or copper status. Normal weight subjects (total n = 2419; 1298 men and 1121 women), were recruited as part of Mashhad Stroke and Heart Association Disorder (MASHAD) Study cohort. They were divided into two groups according to the presence or absence of MetS, defined using IDF criteria. Serum zinc and copper concentrations were determined by atomic absorption. Of the 2419 normal weight adults, 377 had MetS. Of this group, 53.7% and 49.7% had a serum zinc 131 µg/dl (Q4) (p = 0.034), and 18.8% had a serum zinc >95 µg/dl (Q4). Logistic regression analysis was performed to determine the odds ratio (OR) for an association of serum zinc, copper and zinc to copper ratio with MetS in normal weight subjects. The subjects with a serum zinc >95 µg/dl (Q4) had 0.386 [OR: 0.614(95%CI 0.457–0.823)] lower chance of MetS (p = 0.001) and the subjects with a serum copper >131 (Q4) had OR 1.423 (95% CI: 1.09–1.857) higher chance of MetS (p = 0.009). These data remained significant after adjustment for age and sex, for serum zinc and copper, respectively. Furthermore, our results strongly suggested that zinc and copper were the independent risk factor for metabolic syndrome in normal weight subjects. There is an imbalance between serum copper and zinc concentrations among individuals with MONW when compared with normal BMI individuals without MetS. This may increase the risk of individuals with MONW developing conditions associated with this imbalance, such as diabetes and cardiovascular disease. |
| Databáze: | OpenAIRE |
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