Association of the interleukin-10 −592A/C, −1082G/A and −819T/C gene polymorphisms with type 2 diabetes: A meta-analysis
| Autor: | Jing Li, Ji-Min Zhu, Song Wu, Ting-Ting Wang, Ming-Rui Wang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Genotype endocrine system diseases medicine.medical_treatment Type 2 diabetes Biology Bioinformatics Gastroenterology Gene Frequency Polymorphism (computer science) Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Allele Alleles Genetic association Polymorphism Genetic General Medicine medicine.disease Interleukin-10 Interleukin 10 Cytokine Diabetes Mellitus Type 2 Case-Control Studies Meta-analysis |
| Zdroj: | Gene. 521:211-216 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/j.gene.2013.03.072 |
| Popis: | There is more evidence that interleukin-10 (IL-10), as a multifunctional regulatory cytokine of inflammatory responses, may have an important role in type 2 diabetes (T2D). However, genetic association studies that evaluated the relationship between IL-10 gene variants and T2D have produced conflicting results. The aim of this study was to determine whether the IL-10 gene polymorphisms (− 592A/C, − 1082G/A, − 819T/C) conferred susceptibility to T2D through a meta-analysis. A comprehensive search was conducted to examine all the eligible studies. A total of 9 studies involving 2838 T2D patients and 2773 controls were considered in the meta-analysis. Overall, there was no significant association between IL-10 − 592A/C and T2D (A vs C: OR = 0.93, P = 0.625; AA + AC vs CC: OR = 0.89, P = 0.511; AA vs AC + CC: OR = 0.93, P = 0.821). We failed to find the association between the IL-10 − 1082G allele and T2D (OR = 1.04, P = 0.430), but the genotypes of the IL-10 − 1082G/A polymorphism conferred a risk for the development of T2D (GA vs AA: OR = 1.21, P = 0.027; GG + GA vs AA: OR = 1.17, P = 0.048). Analysis of the − 819T/C polymorphism revealed no significant association with T2D (T vs C: OR = 1.04, P = 0.853; TT + TC vs CC: OR = 1.07, P = 0.834; TT vs TC + CC: OR = 1.08, P = 0.824). In conclusion, the present meta-analysis suggests association between the IL-10 − 1082G/A polymorphism and T2D. However, additional well-designed and larger scale primary studies are required to further evaluate the IL-10 gene polymorphisms and T2D. |
| Databáze: | OpenAIRE |
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