Synthesis and biological activity of the new 5-fluorocytosine derivatives, 5′-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5′-carboxylic acid
| Autor: | Kwan-Hee Kim, Keyong-Ho Lee, Youn-Chul Kim, Jiyoung Kim, Moon-Jong Noh, Ho-Jin Park |
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| Rok vydání: | 2002 |
| Předmět: |
Stereochemistry
Carboxylic acid Clinical Biochemistry Flucytosine Pharmaceutical Science Antineoplastic Agents Uronic acid Biochemistry Chemical synthesis Lethal Dose 50 Mice Structure-Activity Relationship chemistry.chemical_compound Capecitabina Drug Discovery Tumor Cells Cultured Animals Humans Leukemia L1210 Cytotoxicity Molecular Biology chemistry.chemical_classification Antitumor activity Chemistry Organic Chemistry Biological activity In vitro Molecular Medicine Indicators and Reagents Drug Screening Assays Antitumor Cell Division |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 12:483-486 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)00782-x |
| Popis: | A series of 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid 6, were synthesized and evaluated for their antitumor activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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