Decreased levels of serum oxytocin in pediatric patients with Attention Deficit/Hyperactivity Disorder
| Autor: | Masaomi Iyo, Tadashi Hasegawa, Yasunori Oda, Tomihisa Niitsu, Yu Kamata, Tsuyoshi Sasaki, Tetsuya Shiraishi, Masatomo Ishikawa, Hideki Komatsu, Hiroshi Kimura, Tamaki Ishima, Tsutomu Kurata, Nobuhisa Kanahara, Kenji Hashimoto, Akihiro Shiina, Tasuku Hashimoto, Junpei Takahashi |
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| Rok vydání: | 2014 |
| Předmět: |
Serum
Male medicine.medical_specialty Attention Deficit Hyperactivity Disorder Adolescent Autism Spectrum Disorder Comorbidity Oxytocin Amygdala behavioral disciplines and activities Executive Function Internal medicine mental disorders medicine Attention deficit hyperactivity disorder Humans Child Biological Psychiatry Biological markers medicine.disease Pathophysiology Drug-naïve Psychiatry and Mental health medicine.anatomical_structure Endocrinology Autism spectrum disorder Attention Deficit Disorder with Hyperactivity Female Psychology Neurotypical hormones hormone substitutes and hormone antagonists Biomarkers medicine.drug Clinical psychology |
| Zdroj: | Psychiatry research. 228(3) |
| ISSN: | 1872-7123 |
| Popis: | Attention Deficit/Hyperactivity Disorder (ADHD) and autism spectrum disorder (ASD) are highly comorbid, and both disorders share executive function deficits. Accumulating evidence suggests that ASD patients have significantly lower peripheral oxytocin (OXT) levels compared with their normal counterparts, and that the repetitive behavior seen in ASD is related to abnormalities in the OXT system. In this study, we investigated whether serum levels of OXT are altered in pediatric patients with ADHD.We measured serum OXT levels: drug naive ADHD (n=23), medicated ADHD (n=13), and age- and sex- matched, neurotypical controls (n=22). Patients were evaluated using the ADHD-RS. Serum levels of OXT in total subjects with ADHD were significantly decreased compared with those of neurotypical controls, and serum levels of OXT in drug naive ADHD patients were significantly lower than those in medicated ADHD patients. Interestingly, there was a significant negative correlation between serum OXT levels and ADHD-RS total scores, as well as ADHD-RS inattentive scores in all ADHD patients. In conclusion, this study suggests that decreased levels of OXT may play a role in the pathophysiology of patients with ADHD and its inherent inattentiveness. |
| Databáze: | OpenAIRE |
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