Remineralisation effect of a dual-phase calcium silicate/phosphate gel combined with calcium silicate/phosphate toothpaste on acid-challenged enamel in situ
| Autor: | Andrew Joiner, Ashok K. Gupta, Fred Schäfer, Mojgan Naeeni, Domenick T. Zero |
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| Rok vydání: | 2014 |
| Předmět: |
Male
business.product_category Sodium Dentistry chemistry.chemical_element Calcium Citric Acid Phosphates Placebos chemistry.chemical_compound Fluorides Double-Blind Method Hardness medicine Humans Tooth Erosion Dental Enamel General Dentistry Tooth Demineralization Aged Toothpaste Cross-Over Studies Enamel paint business.industry Silicates Calcium Compounds Hydrogen-Ion Concentration Middle Aged Phosphate Tooth enamel Cariostatic Agents medicine.anatomical_structure chemistry visual_art Tooth Remineralization Calcium silicate visual_art.visual_art_medium Sodium Fluoride Female business Fluoride Gels Toothpastes Nuclear chemistry Follow-Up Studies |
| Zdroj: | Journal of dentistry. 42 |
| ISSN: | 1879-176X |
| Popis: | To test if a novel dual-phase gel system (calcium silicate and phosphate with 1450 ppmF, as NaF/MFP; TG) combined with a toothpaste (calcium silicate and sodium phosphate with 1450 ppmF, as MFP; TG) was able to re-harden previously acid-challenged enamel to a greater extent than other toothpastes.The study consisted of a double-blind, randomised, cross-over design with four 7-day treatment legs. In each leg, subjects wearing a partial denture holding four demineralised enamel specimens (25 min in 0.3% citric acid, pH3.8) used either the test regimen (TG+TP) or one of the three controls. (placebo TG+TP; Positive Control - placebo TG+marketed 1450 ppmF toothpaste; Negative Control - placebo TG+placebo TP). Enamel specimens were removed after 1, 2, 3 and 7 days. The gel systems were applied once per day for the first three days during which subjects also brushed with the corresponding toothpaste; this was followed by four days use of the toothpastes only. Toothpastes were used in the conventional way brushing twice per day throughout the seven days. The outcome variable was %Surface Microhardness Recovery calculated after three and seven days of in situ treatment.The results showed a statistically significant (p0.001) re-hardening effect for all treatments compared to pre-treatment hardness. After three days and after seven days of in situ treatment significantly greater hardening (p0.05) was found in the samples treated with calcium silicate/phosphate gel system plus calcium silicate/phosphate toothpaste than in the control groups.It is concluded that the test regimen based on the novel dual-phase gel system combined with toothpaste was able to re-harden acid-challenged tooth enamel to a greater extent than a normal fluoride toothpaste.The novel oral care products containing calcium silicate, sodium phosphate salts and fluoride is a new approach to the repair of demineralised enamel. |
| Databáze: | OpenAIRE |
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