Interaction between dietary 1,25‐dihydroxycholecalciferol and calcium and effects of management on the occurrence of tibial dyschondroplasia, leg abnormalities and performance in broiler chickens
Autor: | C. C. Whitehead, J S Rennie, Colin Farquharson, Heather McCormack, E B Mawer, Jacqueline L. Berry |
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Rok vydání: | 1995 |
Předmět: |
medicine.medical_specialty
Hypercalcaemia Calcitriol chemistry.chemical_element Calcium Biology Osteochondrodysplasias Internal medicine medicine Animals Drug Interactions Animal Husbandry Poultry Diseases Meal Dose-Response Relationship Drug Tibial dyschondroplasia Body Weight Broiler Extremities General Medicine Factorial experiment medicine.disease Animal Feed Dose–response relationship Endocrinology chemistry Animal Science and Zoology Energy Metabolism Chickens Food Science medicine.drug |
Zdroj: | British Poultry Science. 36:465-477 |
ISSN: | 1466-1799 0007-1668 |
DOI: | 10.1080/00071669508417792 |
Popis: | 1. Two experiments were performed to compare the relative effectiveness of feeding 1,25-dihydroxycholecalciferol (1,25-DHCC) in minimising leg abnormalities in broilers with other methods and to investigate interactions between dietary 1,25-DHCC and calcium. 2. Adding 5 micrograms 1,25-DHCC/kg to a diet containing 12 g calcium/kg was more effective than early food restriction or meal feeding in preventing leg abnormalities but was found to cause a growth depression. 3. The second experiment, which had a factorial design, with diets containing 7.5, 10.0 and 12.5 g calcium and 0, 2.0, 3.5 and 5.0 micrograms 1,25-DHCC/kg, showed linear and quadratic interactions between these dietary factors. Diets with higher concentrations of both 1,25-DHCC and calcium resulted in growth depression associated with hypercalcaemia. 4. The incidence of tibial dyschondroplasia (TD) at 3 weeks of age was highest with the basal diet containing 7.5 g calcium/kg and was markedly reduced by addition of 1,25-DHCC and/or calcium. The incidence was very low or non-existent when 1,25-DHCC was fed at 3.5 micrograms/kg or greater. 5. Feeding 5 micrograms/kg 1,25-DHCC had no effect on plasma 1,25-DHCC concentrations, although at the higher dietary calcium contents plasma concentrations of 25-hydroxy- and 24,25-dihydroxy-cholecalciferol were lower in those birds fed 1,25-DHCC. 6. It is concluded that 1,25-DHCC is most effective in preventing TD without accompanying growth depression when it is fed in conjunction with diets containing less than 10 g calcium/kg. |
Databáze: | OpenAIRE |
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