Detection of maturity and ligament injury using magic angle directional imaging
| Autor: | Wladyslaw Gedroyc, Djordje Brujic, Richard Meeson, Catherine Van Der Straeten, Mihailo Ristic, Karyn E. Chappell, Donald W. McRobbie |
|---|---|
| Přispěvatelé: | Department Of Trade & Industry (DTI) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
collagen
Scanner Materials science computer.software_genre 030218 nuclear medicine & medical imaging TENDON 03 medical and health sciences TRACKING 0302 clinical medicine Dogs 0903 Biomedical Engineering Voxel magic angle effect Image Interpretation Computer-Assisted medicine Animals Radiology Nuclear Medicine and imaging COLLAGEN FIBRILS FIELD musculoskeletal imaging ANISOTROPY Science & Technology Ligaments medicine.diagnostic_test Orientation (computer vision) Goats Radiology Nuclear Medicine & Medical Imaging Magnetic resonance imaging Magnetic Resonance Imaging Tendon Hindlimb Nuclear Medicine & Medical Imaging medicine.anatomical_structure Ligament Patella ORIENTATION computer Life Sciences & Biomedicine 030217 neurology & neurosurgery Biomedical engineering Tractography MRI |
| Zdroj: | Magnetic Resonance in Medicine |
| Popis: | Purpose: To investigate whether magnetic field–related anisotropies of collagen may be correlated with postmortem findings in animal models. Methods: Optimized scan planning and new MRI data‐processing methods were proposed and analyzed using Monte Carlo simulations. Six caprine and 10 canine knees were scanned at various orientations to the main magnetic field. Image intensities in segmented voxels were used to compute the orientation vectors of the collagen fibers. Vector field and tractography plots were computed. The Alignment Index was defined as a measure of orientation distribution. The knees were subsequently assessed by a specialist orthopedic veterinarian, who gave a pathological diagnosis after having dissected and photographed the joints. Results: Using 50% less scans than reported previously can lead to robust calculation of fiber orientations in the presence of noise, with much higher accuracy. The 6 caprine knees were found to range from very immature (< 3 months) to very mature (> 3 years). Mature specimens exhibited significantly more aligned collagen fibers in their patella tendons compared with the immature ones. In 2 of the 10 canine knees scanned, partial cranial caudal ligament tears were identified from MRI and subsequently confirmed with encouragingly high consistency of tractography, Alignment Index, and dissection results. Conclusion: This method can be used to detect injury such as partial ligament tears, and to visualize maturity‐related changes in the collagen structure of tendons. It can provide the basis for new, noninvasive diagnostic tools in combination with new scanner configurations that allow less‐restricted field orientations. |
| Databáze: | OpenAIRE |
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