Experimental study on abnormal thyroid function in patients with Hashimoto’s thyroiditis caused by interference of thyroid hormone autoantibodies
| Autor: | Wenli Feng, Xiaofang Zhang, Zuoliang Dong |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Thyroid Hormones
medicine.medical_specialty Endocrinology Diabetes and Metabolism Radioimmunoassay Hashimoto Disease Thyroid Function Tests Gastroenterology Thyroiditis Endocrinology Antigens Neoplasm Internal medicine medicine Humans In patient Autoantibodies business.industry Thyroid Autoantibody Abnormal thyroid function Free thyroxine Middle Aged medicine.disease Neoplasm Proteins Thyroxine medicine.anatomical_structure Female Thyroid function business Hormone |
| Zdroj: | Endokrynologia Polska. 72:668-669 |
| ISSN: | 2299-8306 0423-104X |
| DOI: | 10.5603/ep.a2021.0090 |
| Popis: | Introduction: Thyroid hormone autoantibody (THAAb) is one of the important factors affecting the measurement of thyroid function. By studying the results of a patient suffered with Hashimoto's thyroiditis, we fully communicated with the clinician, looked for reasons, and achieved the purpose of restoring the truth and sorting out solutions. Material and Methods: During routine examination by ADVIA-Centaur XP system, we found the test of a case was inconsistent with her clinical manifestations, with abnormal elevation of free thyroxine (FT4) that did not conform to the rule of the hypothalamic-pituitary-thyroid axis. Then, different platforms and demonstration of THAAbs with polyethylene glycol (PEG) precipitation were performed to eliminate the influence of THAAbs. Results: The results showed that the thyroid function of the patient was consistent with the clinical manifestations and conformed to the law of the hypothalamic-pituitary-thyroid axis at Architect-i2000sr platform and Roche-Cobas-601 system. The content of FT4 was significantly reduced and lower than the normal reference range, after the patients' serum was treated with PEG, which was in line with the clinical practice. The serum THAAb titer of the patients was nearly 100 times higher than that of the control group. Conclusions: Once the thyroid function of the patients do not conform to their own laws and clinical manifestations, laboratory staff should consider the interference of THAAbs. It is necessary to change the detection platform and retest the serum after PEG treatment while communicating with the clinicians, which is of great significance to provide a true and accurate result to clinicians and patients. |
| Databáze: | OpenAIRE |
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