Time course of the serum gonadotropin surge, inhibins, and anti-Müllerian hormone in normal newborn males during the first month of life
| Autor: | Luz Andreone, Rodolfo Rey, Stella Campo, Patricia Bedecarrás, Carlos Milani, Silvia Gottlieb, Ignacio Bergadá, M. Gabriela Ropelato, César Bergadá |
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| Rok vydání: | 2006 |
| Předmět: |
Anti-Mullerian Hormone
Male endocrine system medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Ontogeny Clinical Biochemistry Context (language use) Biochemistry Endocrinology Internal medicine medicine Humans Inhibins Testosterone Longitudinal Studies Protein Precursors Glycoproteins biology Biochemistry (medical) Outcome measures Infant Newborn Anti-Müllerian hormone Liter Luteinizing Hormone Testicular Hormones Cross-Sectional Studies biology.protein Female Gonadotropin Follicle Stimulating Hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 91(10) |
| ISSN: | 0021-972X |
| Popis: | Newborns with ambiguous genitalia or males with nonpalpable gonads usually require an early assessment of the presence and functional state of testicular tissue.Our objective was to characterize the precise ontogeny of the serum patterns of gonadotropins, testosterone, anti-Müllerian hormone (AMH), and inhibins in normal newborn boys.We conducted a cross-sectional and longitudinal study.Serum samples were obtained in 57 boys and 13 girls on d 2 of life. A second sample was obtained on d 7, 10, 15, 20, and 30 (boys) and on d 30 (girls).Serum levels of gonadotropins, testosterone, AMH, and inhibins were measured.In males, LH and FSH were undetectable or very low on d 2. By d 7, LH increased to 3.94 +/- 3.19 IU/liter (mean +/- sd) and FSH to 2.04 +/- 1.67 IU/liter. LH/FSH ratios were 0.40 +/- 0.11 (d 2) and 2.02 +/- 0.20 (d 30). AMH rose from 371 +/- 168 pmol/liter (d 2) to 699 +/- 245 pmol/liter (d 30), and inhibin B rose from 214 +/- 86 ng/liter (d 2) to 361 +/- 93 ng/liter (d 30). The inhibin alpha-subunit precursor (pro-alphaC) remained stable during the first month of life. Testosterone levels were 66 +/- 42 ng/dl (d 2), 82 +/- 24 ng/dl (d 20), and 210 +/- 130 ng/dl (d 30). A sexual dimorphism was observed in AMH and inhibin B (lower in girls on d 2 and 30), in LH/FSH ratio (lower in girls on d 30) and in testosterone (lower in girls on d 30).Sertoli cell markers AMH and inhibin B are the earliest useful markers indicating the existence of normal testicular tissue. |
| Databáze: | OpenAIRE |
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