Chemically Triggered Synthesis, Remodeling, and Degradation of Soft Materials
| Autor: | Doo-Hee Lee, James L. Bachman, Xiaolong Sun, James F. Reuther, Nathaniel A. Lynd, Malgorzata Chwatko, Eric V. Anslyn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Polymers
010402 general chemistry Smart material 01 natural sciences Biochemistry Catalysis Article Colloid and Surface Chemistry Amphiphile Copolymer Molecule chemistry.chemical_classification Molecular Structure Chemistry Hydrogels General Chemistry Polymer Small molecule 0104 chemical sciences Cross-Linking Reagents Chemical engineering Click chemistry Click Chemistry Dimerization Hydrophobic and Hydrophilic Interactions Conjugate |
| Zdroj: | J Am Chem Soc |
| Popis: | Polymer topology dictates dynamic and mechanical properties of materials. For most polymers, topology is a static characteristic. In this article, we present a strategy to chemically trigger dynamic topology changes in polymers in response to a specific chemical stimulus. Starting with a dimerized PEG and hydrophobic linear materials, a lightly cross-linked polymer, and a cross-linked hydrogel, transformations into an amphiphilic linear polymer, lightly cross-linked and linear random copolymers, a cross-linked polymer, and three different hydrogel matrices were achieved via two controllable cross-linking reactions: reversible conjugate additions and thiol-disulfide exchange. Significantly, all the polymers, before or after topological changes, can be triggered to degrade into thiol- or amine-terminated small molecules. The controllable transformations of polymeric morphologies and their degradation herald a new generation of smart materials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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