Relationship between the anti-inflammatory and irritant properties of inflammatory exudate
| Autor: | R. Hicks, D. C. Atkinson |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
Exudate Pathology medicine.medical_specialty medicine.drug_class Anti-Inflammatory Agents Pharmacology Carrageenan medicine.disease_cause Anti-inflammatory chemistry.chemical_compound Edema medicine Animals Mode of action biology Chemistry Systematic Pharmacology Adrenalectomy Exudates and Transudates biology.organism_classification Rats Sponge Irritants Biological Assay Irritation medicine.symptom Inflammatory exudate Dialysis |
| Zdroj: | British Journal of Pharmacology. 41:480-487 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1971.tb08045.x |
| Popis: | Summary 1 Using the rat paw oedema assay procedure a comparison was made between the anti-inflammatory and irritant properties of the inflammatory exudate obtained from polyester sponges implanted subcutaneously in adrenalectomized rats. Where necessary, comparison was also made with a known counter-irritant, carrageenin. 2 A significant correlation between the anti-inflammatory and irritant properties of sponge exudate was observed when each parameter was determined in relation to dose. A similar result was obtained with carrageenin. 3 A comparison of the two activities of sponge exudate samples harvested at various times following sponge implantation did not give a significant correlation although in each case significant anti-inflammatory activity was accompanied by marked irritation. 4 Time-effect curves of the two activities of sponge exudate showed a significant correlation over the time period examined. However, no such correlation was obtained using carrageenin. 5 Both activities of sponge exudate were retained following dialysis. 6 These findings are discussed in relation to a counter-irritant mode of action for sponge exudate. |
| Databáze: | OpenAIRE |
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