Diarylprolinol as a Ligand for Enantioselective Alkynylation of Cyclic Imines
| Autor: | José R. Pedro, Alicia Monleon, Carlos Vila, Lode De Munck |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Trifluoromethyl
010405 organic chemistry Ligand Dimethylzinc Enantioselective synthesis General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Prolinol Catalysis chemistry.chemical_compound chemistry Alkynylation Catàlisi Alcohols Organic chemistry Methanol Química orgànica |
| Zdroj: | De Munck, Lode Monleón Ventura, Alicia Vila Descals, Carlos Pedro, José Ramón 2017 Diarylprolinol as a Ligand for Enantioselective Alkynylation of Cyclic Imines Advanced Synthesis & Catalysis 359 9 1582 1587 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname |
| Popis: | An easily accessible prolinol derived ligand, (S)-bis(3,5-bis(trifluoromethyl)phenyl)(pyrrolidin-2-yl)methanol, has been efficiently applied in the catalytic enantioselective addition of terminal alkynes to cyclic imines using dimethylzinc (Me2Zn) under mild reaction conditions. The developed catalytic system led to chiral propargylic sulfamidates with high yields (up to 97%) and excellent enantioselectivities (up to 97% ee). |
| Databáze: | OpenAIRE |
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