Gender, race and socioeconomic influence on diagnosis and treatment of thyroid disorders in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Autor: I. M. Bensenor, Rodrigo Díaz Olmos, Paulo A. Lotufo, Estela M. L. Aquino, R.C. de Figueiredo
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
Pediatrics
Longitudinal study
Medicine (General)
endocrine system diseases
Physiology
Cross-sectional study
Levothyroxine
Logistic regression
Biochemistry
Hyperthyroidism
Medicine
Longitudinal Studies
General Pharmacology
Toxicology and Pharmaceutics
Biology (General)
lcsh:QH301-705.5
lcsh:R5-920
General Neuroscience
Thyroid
Thyroid dysfunction
General Medicine
Middle Aged
medicine.anatomical_structure
Socioeconomic status
Female
lcsh:Medicine (General)
Brazil
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Cohort study
Adult
medicine.medical_specialty
endocrine system
Race
QH301-705.5
Immunology
Biophysics
Ocean Engineering
Family income
R5-920
Hypothyroidism
Humans
Clinical Investigation
Sex Distribution
Psychiatry
Aged
business.industry
Racial Groups
Gender
Cell Biology
Thyroxine
Cross-Sectional Studies
Socioeconomic Factors
lcsh:Biology (General)
Treatment of thyroid disorders
business
Zdroj: Brazilian Journal of Medical and Biological Research, Vol 48, Iss 8, Pp 751-758 (2015)
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research v.48 n.8 2015
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Volume: 48, Issue: 8, Pages: 751-758, Published: 23 JUN 2015
Popis: Thyroid diseases are common, and use of levothyroxine is increasing worldwide. We investigated the influence of gender, race and socioeconomic status on the diagnosis and treatment of thyroid disorders using data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a multicenter cohort study of civil servants (35-74 years of age) from six Brazilian cities. Diagnosis of thyroid dysfunction was by thyrotropin (TSH), and free thyroxine (FT4) if TSH was altered, and the use of specific medications. Multivariate logistic regression models were constructed using overt hyperthyroidism/hypothyroidism and levothyroxine use as dependent variables and sociodemographic characteristics as independent variables. The frequencies of overt hyper- and hypothyroidism were 0.7 and 7.4%, respectively. Using whites as the reference ethnicity, brown, and black race were protective for overt hypothyroidism (OR=0.76, 95%CI=0.64-0.89, and OR=0.53, 95%CI=0.43-0.67, respectively, and black race was associated with overt hyperthyroidism (OR=1.82, 95%CI=1.06-3.11). Frequency of hypothyroidism treatment was higher in women, browns, highly educated participants and those with high net family incomes. After multivariate adjustment, levothyroxine use was associated with female gender (OR=6.06, 95%CI=3.19-11.49) and high net family income (OR=3.23, 95%CI=1.02-10.23). Frequency of hyperthyroidism treatment was higher in older than in younger individuals. Sociodemographic factors strongly influenced the diagnosis and treatment of thyroid disorders, including the use of levothyroxine.
Databáze: OpenAIRE
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